Mechanistically, RNF146 directly interacts with poly(ADP-ribose) through its WWE domain, and promotes degradation of PARsylated proteins. Using proteomics ...
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Jan 8, 2015 · Abstract. Protein poly(ADP-ribosyl)ation (PARylation) has a role in diverse cellular processes such as DNA repair, transcription, Wnt signalling ...
Missing: Ribosy | Show results with:Ribosy
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation ...
Missing: Ribosy | Show results with:Ribosy
Jan 18, 2024 · proteins are known E3 ubiquitin ligases, our results suggest that protein poly(ADP-ribosyl)ation may be a general mechanism to target ...
Aug 8, 2011 · Poly(ADP-ribose) (PAR) is a cell-signaling molecule that mediates changes in protein function through binding at PAR binding sites. Here we ...
Abstract. The RING finger protein Rnf146 encodes an E3 ubiquitin ligase capable of targeting poly-ADP-ribosylated substrates for proteasomal degradation. Rnf146 ...
Dec 19, 2011 · Since many WWE do- main-containing proteins are known E3 ubiquitin ligases, our results suggest that protein poly(ADP-ribosyl)ation may be a ...
May 18, 2017 · In Brief. Yang et al. show that Dtx3L/Parp9, a heterodimeric complex that has both E3 and ADP-ribosylation activities, mediates.
... E3 domains are constitutively able to bind and activate an E2~Ub conjugate to transfer ubiquitin to substrates. Protein poly(ADP-ribosyl)ation (PARylation) ...
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RING (Really Interesting New Gene) E3 ligases position the E2 and the target substrate for direct ubiquitin transfer [17], [18]. This review focuses on a RING ...